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The OCS Heart (pictured above), OCS Lung and OCS Liver from TransMedics utilize several grades of Makrolon polycarbonate from Covestro.
The OCS Heart (pictured above), OCS Lung and OCS Liver from TransMedics utilize several grades of Makrolon polycarbonate from Covestro.

To improve the way organs are preserved during transportation, TransMedics, Inc. developed the Organ Care System (OCS), an innovative, portable system that delivers warm, nutrient-rich blood to the organ, allowing it to function outside of the body and enabling organ optimization and assessment.

Cold ischemic storage has been the traditional method for organ preservation during transplantation. However, this technique has limitations, such as a narrow window for safe transport, the potential for damage even within safe time limits and the inability to test organ function.

TransMedics has three OCS products – OCS Heart, OCS Lung and OCS Liver, each of which has three primary components: a portable console with a wireless monitor, a disposable perfusion set and nutrient-enriched solutions.

The perfusion set’s clear enclosure protects the organ using Makrolon 2458 and Makrolon Rx1452 polycarbonates from Covestro, while the attached connectors utilize Makrolon Rx1805.

“Makrolon polycarbonates offer the combination of transparency and toughness needed for this medical device,” said John Sullivan, vice president of engineering, TransMedics, Inc.

Makrolon polycarbonates for medical applications offer several beneficial attributes for the OCS platform, including:

  • Dimensional stability
  • Impact and chemical resistance
  • Suitable for sterilization
  • Biocompatible according to many ISO 10993-1 test requirements

According to Covestro, Makrolon 2458 and Makrolon Rx1452 polycarbonates are ideal materials for medical devices, featuring a low viscosity and easy-release properties.

Safely transporting organs can literally mean the difference between life and death,” said Lauren Zetts, Americas market manager, Healthcare – Polycarbonates, Covestro LLC. “It’s very gratifying that our materials play a role in helping TransMedics fulfill its mission to deliver healthy transplants in a timely manner.”

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