Home
Search History
Clear History
{{item.search_key}}
Hot Searches
Change
{{item.name}}
{{item.english_name}}
Subscribe eNews
Once A Week Once Every Two Weeks
{{sum}}
{{sum}}
Login

Please Login

Subscribe To Tags, See What You Want To See

Sign Up For Events, Expand your network

Unlock Private Messages, Participate In Interactions

 Register

Hi.{{userInfo.company_name_english||userInfo.truename_english}} Hi.{{userInfo.truename||userInfo.phone||userInfo.email}}

Applications

EREMA to show high-quality recycling solutions at CHINAPLAS 2026

ENGEL’s high-performance automotive solutions at CHINAPLAS 2026

ST BlowMoulding to unveil multiple innovative hollow moulding solutions at CHINAPLAS 2026

Products

Chambroad to highlight specialization and innovation at CHINAPLAS 2026

Evonik displays its latest solutions at CHINAPLAS 2026

Kistler’s cavity pressure sensor for injection molding trainings

Activities

  • CHINAPLAS 2026：VDMA “The Power of Plastics” forum highlights digitalization and circularity

  • Must-attend: CHINAPLAS x CPRJ Plastics Recycling and Circular Economy Conference in Shanghai

  • Beyond procurement: Exploring the concurrent events at CHINAPLAS 2026

Pictorial

News Videos

Ready for CHINAPLAS 2026? Two tools for your visit

Interview: Ada Leung, General Manager, Adsale Exhibition Services Ltd.

KUMHO-SUNNY: Your selection logic is already outdated!

Conference Videos

[Mandarin session: Highlights] Covestro: Innovative thermal conductive material solution for new-generation network devices

[Mandarin session: Highlights] Covestro: The Material Effect: Empowering Innovations in Solar-Storage-Charging Smart Energy and Data Center Applications

[Mandarin session: Highlights] Covestro: In-mold Coating (DC/IMC) Technology - Facilitating Personalized Design for Automotive Interior and Exterior Components

Corporate/Product Videos

About Dow

B Series brush machine

Innovative PVC Compounds for Global Manufacturing | Visit Us Booth 6.2A 39 at CHINAPLAS

News
NEW
HOT
 Events
NEW
HOT
 SPE Asia
NEW
HOT
 Special
NEW
HOT
 Live
NEW
HOT
 eNews
NEW
HOT
 Essential Guide
NEW
HOT
 Event Calendar
NEW
HOT
 Survey
NEW
HOT
 CHINA INSIGHT
NEW
HOT

Home > News > Recycling

Engineering thermostable enzyme depolymerize semi-crystalline PET even faster

Source：Adsale Plastics Network Date ：2022-09-02 Editor ：JK

Researchers from the Manchester Institute of Biotechnology (MIB) have developed a new enzyme engineering platform to improve plastic degrading enzymes through directed evolution. To illustrate the utility of the platform, they have engineered an enzyme that can successfully degrade PET.

 

In recent years, the enzymatic recycling of plastics has emerged as an attractive and environmentally friendly strategy to help alleviate the problems associated with plastic waste. Although there are a number of existing methods for recycling plastics, enzymes could potentially offer a more cost-effective and energy efficient alternative.

 

Also, they could be used to selectively breakdown specific components of mixed plastic waste streams that are currently difficult to recycle using existing technologies. 

 

Although promising as a technology, there are considerable hurdles that need to be overcome for enzymatic plastic recycling to be used widely on a commercial scale. One challenge, for instance, is that natural enzymes with the ability to break down plastics typically are less effective and are unstable under the conditions needed for an industrial-scale process. 


To address these limitations, in a paper released in Nature Catalysis, researchers from The University of Manchester have reported a new enzyme engineering platform that can quickly improve the properties of plastic degrading enzymes to help make them more suitable for plastic recycling at large scales.


1_web.jpg

HotPETase can depolymerize semi-crystalline PET more rapidly than previously reported enzymes.


Their integrated and automated platform can successfully assess the plastic degradation ability of around 1000 enzyme variants per day. 

 

Dr. Elizabeth Bell, who led the experimental work at the MIB, stated, “The accumulation of plastic in the environment is a major global challenge. For this reason, we were keen to use our enzyme evolution capabilities to enhance the properties of plastic degrading enzymes to help alleviate some of these problems.”

 

"We are hopeful that in the future our scalable platform will allow us to quickly develop new and specific enzymes are suitable for use in large-scale plastic recycling processes."

 

To test their platform, they went on to develop a new enzyme, HotPETase, through the directed evolution of IsPETase. IsPETase is a recently discovered enzyme produced by the bacterium Ideonella sakaiensis, which can use PET as a carbon and energy source.

 

While IsPETase has the natural ability to degrade some semi-crystalline forms of PET, the enzyme is unstable at temperatures above 40°C, far below desirable process conditions.

 

This low stability means that reactions must be run at temperatures below the glass transition temperature of PET (~65°C), which leads to low depolymerization rates.

 

To address this limitation, the team has developed a thermostable enzyme, HotPETase, which is active at 70°C, which is above the glass transition temperature of PET. 

 

This enzyme can depolymerize semi-crystalline PET more rapidly than previously reported enzymes and can selectively deconstruct the PET component of a laminated packaging material, highlighting the selectivity that can be achieved by enzymatic recycling. 

 

Professor Anthony Green, Lecturer in Organic Chemistry of MIB, commented, “The development of HotPETase nicely illustrates the capabilities of our enzyme engineering platform. Moving forward, we are hopeful that our platform will prove useful for developing more efficient, stable, and selective enzymes for recycling a wide range of plastic materials.”

 Like 丨  {{details_info.likes_count}}
Recycling
PET
 SACMI (SHANGHAI) MACHINERY EQUIPMENT CO., LTD.      
 DONGGUAN DEHUA PRECISION MOLD CO., LTD      
 ZHANGJIAGANG XINRONG MACHINERY CO.,LTD      
 JUHESHUN ADVANCED MATERIALS CO., LTD.      
 HEFEI TAIHE INTELLIGENT TECHNOLOGY GROUP CO.,LTD.      
 HANGZHOU BOSOM NEW MATERIALS TECHNOLOGY CO.,LTD.      
 BEIJING ENERGY ENGINEERING TECHNOLOGIES CO.,LTD.      
 WINDORA MATERIALS LLC      
 GREENWICH (CHINA) TECHNOLOGY DEVELOPMENT LIMITED      
 GREENCORE RESOURCES LIMITED      
 LINKER NEW MATERIALS CO., LTD      
 Coperion GmbH      
 SHANGHAI HAWKWAY PROCESS SOLUTIONS CO., LTD      
 GUANGXI HENGYI NEW MATERIALS CO., LTD.      
 TAIZHOU MIXIN MACHINERY CO., LTD.      
 ZHEJIANG ROTOUN PLASTIC TECHNOLOGY CORP.      
 GUANGDONG GUOHENG YOUHE ADVANCED MATERIALS CO., LTD.      
 KADIDE      
 GUANGXI WUZHOU GUOLONG RECYCLABE RESOURCES DEVELOPMENT CO., LTD.      
 SUZHOU BECHTON PLASTIC MACHINERY CO., LTD      
 Zhejiang Future Petrochemical Co.,ltd      
 YUYAO KAWAGUCHI Manufacturing Co., Ltd.      
 Beijing Chemical Industry Group CO.,LTD      
 KOKSAN (NANTONG) NEW MATERIAL CO,LTD      
 LINYI HUASU ELECTRONIC TECHNOLOGY CO., LTD.      
 ANHUI HAO YUAN CHEMICAL GROUP CO., LTD.      
 GUANGDONG ENMEI CHEMICAL TECHNOLOGY CO., LTD      
 ANHUI ZHONGXIN HONGWEI TECHNOLOGY CO.,LTD      
 FUJIAN NAN'AN STAR RUBBER&PLASTIC MACHINERY CO., LTD.      
 TAIZHOU HUANGYAN TAIXIANG PLASTIC MACHINERY CO.,LTD.      
 ZHANGJIAGANG GREENLANDPLAST MACHINERY CO.,LTD      
 FUJIAN YANGZHU NEW MATERIAL SCIENCE & TECHNOLOGY CO., LTD      
 HUBEI XINJIANSHI MACHINERY TECHNOLOGY CO.,LTD      
 HEBEI GELIA PLASTIC MACHINERY SALES COMPANY      
 HENAN SHUOPENG NEW MATERIALS TECHNOLOGY CO., LTD      
 FOSHAN SHUNDE MINGSANFENG MOULD CO., LTD.      

The content you're trying to view is for members only. If you are currently a member, Please login to access this content.   Login

Source：Adsale Plastics Network Date ：2022-09-02 Editor ：JK

Researchers from the Manchester Institute of Biotechnology (MIB) have developed a new enzyme engineering platform to improve plastic degrading enzymes through directed evolution. To illustrate the utility of the platform, they have engineered an enzyme that can successfully degrade PET.

 

In recent years, the enzymatic recycling of plastics has emerged as an attractive and environmentally friendly strategy to help alleviate the problems associated with plastic waste. Although there are a number of existing methods for recycling plastics, enzymes could potentially offer a more cost-effective and energy efficient alternative.

 

Also, they could be used to selectively breakdown specific components of mixed plastic waste streams that are currently difficult to recycle using existing technologies. 

 

Although promising as a technology, there are considerable hurdles that need to be overcome for enzymatic plastic recycling to be used widely on a commercial scale. One challenge, for instance, is that natural enzymes with the ability to break down plastics typically are less effective and are unstable under the conditions needed for an industrial-scale process. 


To address these limitations, in a paper released in Nature Catalysis, researchers from The University of Manchester have reported a new enzyme engineering platform that can quickly improve the properties of plastic degrading enzymes to help make them more suitable for plastic recycling at large scales.


1_web.jpg

HotPETase can depolymerize semi-crystalline PET more rapidly than previously reported enzymes.


Their integrated and automated platform can successfully assess the plastic degradation ability of around 1000 enzyme variants per day. 

 

Dr. Elizabeth Bell, who led the experimental work at the MIB, stated, “The accumulation of plastic in the environment is a major global challenge. For this reason, we were keen to use our enzyme evolution capabilities to enhance the properties of plastic degrading enzymes to help alleviate some of these problems.”

 

"We are hopeful that in the future our scalable platform will allow us to quickly develop new and specific enzymes are suitable for use in large-scale plastic recycling processes."

 

To test their platform, they went on to develop a new enzyme, HotPETase, through the directed evolution of IsPETase. IsPETase is a recently discovered enzyme produced by the bacterium Ideonella sakaiensis, which can use PET as a carbon and energy source.

 

While IsPETase has the natural ability to degrade some semi-crystalline forms of PET, the enzyme is unstable at temperatures above 40°C, far below desirable process conditions.

 

This low stability means that reactions must be run at temperatures below the glass transition temperature of PET (~65°C), which leads to low depolymerization rates.

 

To address this limitation, the team has developed a thermostable enzyme, HotPETase, which is active at 70°C, which is above the glass transition temperature of PET. 

 

This enzyme can depolymerize semi-crystalline PET more rapidly than previously reported enzymes and can selectively deconstruct the PET component of a laminated packaging material, highlighting the selectivity that can be achieved by enzymatic recycling. 

 

Professor Anthony Green, Lecturer in Organic Chemistry of MIB, commented, “The development of HotPETase nicely illustrates the capabilities of our enzyme engineering platform. Moving forward, we are hopeful that our platform will prove useful for developing more efficient, stable, and selective enzymes for recycling a wide range of plastic materials.”

全文内容需要订阅后才能阅读哦~
立即订阅
AdsaleCPRJ.com A1 - EMP - EN Jiangyin Yuexing Machinery Co., Ltd.
SCREW BARREL JIANGSU BEILIJIA MACHINERY CO.,LTD. YUYAO KAWAGUCHI Manufacturing Co., Ltd.

Recommended Articles

Recycling
EREMA to show high-quality recycling solutions at CHINAPLAS 2026
 2026-04-14
Recycling
ST BlowMoulding to unveil multiple innovative hollow moulding solutions at CHINAPLAS 2026
 2026-04-13
Recycling
Recycling production waste from diaper manufacturing
 2026-04-08
Recycling
Report: Unraveling the secrets to a thriving plastic recycling sector
 2026-04-04
Recycling
Röhm invests in chemical recycling
 2026-04-02
Recycling
Japanese plastics market accelerates green material transformation
 2026-03-26
Gienkee Patented Infrared Heater Band Specializing in Modified Composites Deepening Flame Retardan
One of the earliest professional manufacturers of melt gear ZHEJIANG JUNHENG MACHINERY MANUFACTURING CO., LTD Intaglio Printing Ink Manufacturer
  • Must See
    • News
    Images
    Watch it
1
Haitian’s annual overseas sales up 26.4%
2
CHINAPLAS: Re-mall recognized for producing high-quality PCR materials
3
CHINAPLAS: Go beyond with plastic solutions of Evonik
4
All-round beverage packaging solutions from SACMI at CHINAPLAS
5
NGC to showcase four core gearbox series at CHINAPLAS 2026
1
ALPLA: Global packaging, empowering China
2
Is Your Mold Supplier Really Giving You Peace of Mind?
3
【Mandarin session: Webinar playback】HUSKY：From Injection Molding Machines to Temperature Controllers – Diversified Product Portfolio Breaks Through Molding Challenges and Empowers Advanced Applications in End-Use Segmented Markets – Pre-Show Analysis for Chinaplas
4
injection mould-labubu
5
Brückner presents new member and debut of NoSho technology at CHINAPLAS 2026
  • Hot Specials

You May Be Interested In

Change
  • People
  • Company
loading... No Content
{{[item.truename,item.truename_english][lang]}} {{[item.company_name,item.company_name_english][lang]}} {{[item.job_name,item.name_english][lang]}}
{{[item.company_name,item.company_name_english][lang]}} Company Name    {{[item.display_name,item.display_name_english][lang]}}  

Polyurethane Investment Medical Carbon neutral Reduce cost and increase efficiency CHINAPLAS Financial reports rPET INEOS Styrolution Evonik Borouge Polystyrene (PS) mono-material Sustainability Circular economy BASF SABIC Multi-component injection molding machine All-electric injection molding machine Thermoforming machine

Engineering thermostable enzyme depolymerize semi-crystalline PET even faster

识别右侧二维码，进入阅读全文
下载
x 关闭
订阅
亲爱的用户，请填写一下信息
I have read and agree to the 《Terms of Use》 and 《Privacy Policy》
立即订阅
Top
Feedback
Chat
News
Market News
Applications
Products
Video
In Pictures
Specials
Activities
eBook
Front Line
Plastics Applications
Chemicals and Raw Material
Processing Technologies
Products
Injection
Extrusion
Auxiliary
Blow Molding
Mold
Hot Runner
Screw
Applications
Packaging
Automotive
Medical
Recycling
E&E
LED
Construction
Others
Events
Conference
Webinar
CHINAPLAS
CPS+ eMarketplace
Official Publications
CPS eNews
Media Kit
Social Media
Facebook
Linkedin
Adsale Group ｜  About Us ｜  Terms of Use ｜  Privacy Policy ｜  Contact Us ｜  Media Kit ｜  Consent Letter for Processing Personal Data ｜