The coronavirus, SARS-CoV-2, which is responsible for the current COVID-19 pandemic, is transmitted between people mainly via respiratory droplets, but it is known that the virus remains stable on various surfaces for days.

In light of the possibility that the virus can spread through contaminated surfaces, it is important to be able to sterilize surfaces with high contamination potential, such as doorknobs, elevator buttons or handrails in public areas in general, and in hospitals and clinics in particular.

However, current disinfectants are mainly based on chemicals such as poisonous sodium hypochlorite (bleach) or alcohol, both of which provide only a temporary measure until the next exposure to the virus.

Prof. Angel Porgador, from the Department of Microbiology, Immunology and Genetics at Ben-Gurion University (BGU) and the National Institute of Biotechnology in the Negev (NIBN), and Dr. Mark Schvartzman, the Department of Materials Engineering at BGU, are developing novel surface coatings that will have a long term effect, and contain nanoparticles of safe metal ions and polymers with anti-viral and anti-microbial activity.

Certain metals can be lethal, even in small quantities, for viruses and bacteria and are not poisonous to humans. In proof of concept experiments, in which also PhD students Yariv Greenshpan and Esti Toledo, and postdoc Guillaume Le Saux participated, the researchers assessed the effect of surfaces coated with nanoparticles of various metals on the infectivity of lentiviruses, which belong to the HIV family, in human cells.

Esti Toledo and Guillaume Le Saux at Dr. Mark Schvartzman's laboratory. (Photo: Dani Machlis)

Findings show that surfaces coated with copper nanoparticles strongly block infection of the cells by the virus. These ongoing experiments show a huge potential for copper ions in preventing surface-mediated infection with SARS-CoV-2.

Based on these findings, the researchers are developing anti-viral coatings that can be painted or sprayed on surfaces. The coatings are based on polymers, which are the starting materials of plastics and paints, and contain nanoparticles of copper and other metals. The nanoparticles embedded in the polymer will enable controlled release of metal ions onto the coated surface.

Studies show that these ions have a strong anti-viral effect, which can eradicate virus particles that adhere to the surface. Because the release of ions is extremely slow, the coating can be effective for a long period of time – weeks and even months, and it will reduce the infectivity of the virus particles by more than 10-fold.

Josh Peleg, CEO, BGN Technologies, said, "The need to develop anti-viral coatings has greatly increased recently, with the SARS-CoV-2 outbreak, and this need will likely remain high even after the pandemic ends, due to increased awareness."

The research activity of Prof. Porgador and Dr. Schvartzman is part of the coronavirus research task force, founded by Prof. Daniel Chamovitz, President of BGU. To support this activity, it was decided to divert research funds in order to find rapid solutions for various challenges associated with the coronavirus pandemic.

The invention received the support of the Israel Innovation Authority, in response to a call for proposals for coping with the coronavirus. The project is one of 27 proposals submitted to the Israel Innovation Authority by BGN Technologies, the technology transfer company of BGU, based on innovative and diverse inventions of researchers at BGU and the National Institute for Biotechnology in the Negev (NIBN) for the prevention, diagnosis and treatment of COVID-19.

The coronavirus, SARS-CoV-2, which is responsible for the current COVID-19 pandemic, is transmitted between people mainly via respiratory droplets, but it is known that the virus remains stable on various surfaces for days.

In light of the possibility that the virus can spread through contaminated surfaces, it is important to be able to sterilize surfaces with high contamination potential, such as doorknobs, elevator buttons or handrails in public areas in general, and in hospitals and clinics in particular.

However, current disinfectants are mainly based on chemicals such as poisonous sodium hypochlorite (bleach) or alcohol, both of which provide only a temporary measure until the next exposure to the virus.

Prof. Angel Porgador, from the Department of Microbiology, Immunology and Genetics at Ben-Gurion University (BGU) and the National Institute of Biotechnology in the Negev (NIBN), and Dr. Mark Schvartzman, the Department of Materials Engineering at BGU, are developing novel surface coatings that will have a long term effect, and contain nanoparticles of safe metal ions and polymers with anti-viral and anti-microbial activity.

Certain metals can be lethal, even in small quantities, for viruses and bacteria and are not poisonous to humans. In proof of concept experiments, in which also PhD students Yariv Greenshpan and Esti Toledo, and postdoc Guillaume Le Saux participated, the researchers assessed the effect of surfaces coated with nanoparticles of various metals on the infectivity of lentiviruses, which belong to the HIV family, in human cells.

Esti Toledo and Guillaume Le Saux at Dr. Mark Schvartzman's laboratory. (Photo: Dani Machlis)

Findings show that surfaces coated with copper nanoparticles strongly block infection of the cells by the virus. These ongoing experiments show a huge potential for copper ions in preventing surface-mediated infection with SARS-CoV-2.

Based on these findings, the researchers are developing anti-viral coatings that can be painted or sprayed on surfaces. The coatings are based on polymers, which are the starting materials of plastics and paints, and contain nanoparticles of copper and other metals. The nanoparticles embedded in the polymer will enable controlled release of metal ions onto the coated surface.

Studies show that these ions have a strong anti-viral effect, which can eradicate virus particles that adhere to the surface. Because the release of ions is extremely slow, the coating can be effective for a long period of time – weeks and even months, and it will reduce the infectivity of the virus particles by more than 10-fold.

Josh Peleg, CEO, BGN Technologies, said, "The need to develop anti-viral coatings has greatly increased recently, with the SARS-CoV-2 outbreak, and this need will likely remain high even after the pandemic ends, due to increased awareness."

The research activity of Prof. Porgador and Dr. Schvartzman is part of the coronavirus research task force, founded by Prof. Daniel Chamovitz, President of BGU. To support this activity, it was decided to divert research funds in order to find rapid solutions for various challenges associated with the coronavirus pandemic.

The invention received the support of the Israel Innovation Authority, in response to a call for proposals for coping with the coronavirus. The project is one of 27 proposals submitted to the Israel Innovation Authority by BGN Technologies, the technology transfer company of BGU, based on innovative and diverse inventions of researchers at BGU and the National Institute for Biotechnology in the Negev (NIBN) for the prevention, diagnosis and treatment of COVID-19.